The Future of Advanced Skincare is Vegan - and Already Here at 5 Squirrels

At 5 Squirrels, we don’t follow trends in skincare - we set them. 

From Marine DNA to Bioengineered Skin Science

One of the biggest shifts in advanced skincare is the move away from salmon-derived PDRN toward vegan, biotech-engineered skin renewal technologies.

Traditionally, PDRN has been associated with supporting:

• Post-procedure skin recovery

• Collagen support

• Reduction in visible inflammation

• Skin repair and renewal

Traditionally sourced from salmon DNA, growing demand is now driving the development of more ethical, scalable, and sustainable alternatives.

That innovation is accelerating progress in:

• Algae-derived biotechnology

• Fermentation-based actives

• Biomimetic signalling systems

• Advanced peptide and exosome-inspired technologies

100% Vegan — Always

At 5 Squirrels, all formulations are, and always will be, 100% vegan.

We develop advanced skin-support systems using biotechnology rather than animal-derived ingredients — combining clinical innovation with modern expectations around sustainability, ethics, and performance.

• Vegan by design

• Science-led in formulation

• Clinically aligned in approach

• Focused on long-term skin health and longevity1

Super XO+ Longevity Complex: Built for the Next Generation of Skincare

Our Super XO+ Longevity Complex reflects the next generation of advanced skincare innovation.

Combining vegan polynucleotide technology with exosome-inspired signalling technology, the formula is designed to support skin recovery, resilience, and overall skin quality.

Rather than focusing on a single mechanism, the formulation is designed to support multiple aspects of skin health, including:

• Skin communication pathways

• Skin barrier recovery

• Visible redness and skin comfort

• Support for skin structure and firmness

• Post-treatment skin support

  
  

Why this Combination Matters

Healthy-looking skin functions best when multiple support systems work together.

Within Super XO+:

• Exosome-inspired technology helps support skin communication processes associated with skin renewal and recovery

• Vegan polynucleotide technology helps support hydration, skin comfort, and the appearance of overall skin quality

Together, they help support:

• Smoother-looking skin

• Improved skin hydration and texture

• Firmer-looking skin

• Improved skin resilience

• Reduction in visible signs of skin ageing

• Overall skin recovery and appearance following professional treatments

Advanced skincare is evolving - and we are leading the way.

At 5 Squirrels, we continue to develop science-led, 100% vegan skincare that keeps our clinic partners at the forefront of modern aesthetic practice. By combining advanced biotechnology with clinically aligned formulation strategies, we ensure the products in Your Signature Range remain innovative, high-performing, and fully aligned with the future of professional skincare.